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- Title
Role of reactive oxygen species (ROS) in apoptosis induction.
- Authors
Simon, H U; Haj-Yehia, A; Levi-Schaffer, F
- Abstract
Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largely mediated by direct or indirect ROS action. On the other hand, ROS have also anti-apoptotic effects. This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells.
- Publication
Apoptosis : an international journal on programmed cell death, 2000, Vol 5, Issue 5, p415
- ISSN
1360-8185
- Publication type
Journal Article
- DOI
10.1023/a:1009616228304