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- Title
Bcr-Abl and inhibition of apoptosis in chronic myelogenous leukemia cells.
- Authors
Fernandez-Luna, J L
- Abstract
Chronic myelogenous leukemia (CML) cells are highly resistant to apoptosis induced by chemotherapeutic drugs. The observation that production of Bcr-Abl is the initiating event in CML has focussed attention on the survival signals triggered by this oncogene. A number of signal transducers and transcription factors have been associated with the antiapoptotic phenotype of CML cells, some of which lead to the expression and/or activation of members of the Bcl-2 family of apoptosis modulators, such as Bcl-xL and Bad. In this article, recent advances in understanding the antiapoptotic pathways triggered by Bcr-Abl in CML cells, are discussed.
- Publication
Apoptosis : an international journal on programmed cell death, 2000, Vol 5, Issue 4, p315
- ISSN
1360-8185
- Publication type
Journal Article
- DOI
10.1023/a:1009623222534