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- Title
Interleukin-10 levels are often elevated in serum of adults with Hodgkin's disease and are associated with inferior failure-free survival.
- Authors
Sarris, A H; Kliche, K O; Pethambaram, P; Preti, A; Tucker, S; Jackow, C; Messina, O; Pugh, W; Hagemeister, F B; McLaughlin, P; Rodriguez, M A; Romaguera, J; Fritsche, H; Witzig, T; Duvic, M; Andreeff, M; Cabanillas, F
- Abstract
Interleukin-10 (IL-10) is a pleiotropic cytokine that protects B- or T-lymphocytes and hemopoietic progenitors from apoptosis induced by doxorubicin, glucocorticoids, or deprivation of growth factors. IL-10 is also immunosupressive, and tumor cells secreting IL-10 can grow in syngeneic or allogeneic hosts, and can inhibit the generation of tumor-specific cytotoxic T cells. Hodgkin-Reed-Sternberg cells are derived from follicular center B cells and they may be latently infected by EBV. When this occurs they often express IL-10. Based on these considerations we investigated the relationship between pretreatment serum IL-10 levels and failure-free survival (FFS) in Hodgkin's disease (HD).
- Publication
Annals of oncology : official journal of the European Society for Medical Oncology, 1999, Vol 10, Issue 4, p433
- ISSN
0923-7534
- Publication type
Journal Article
- DOI
10.1023/a:1008301602785