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- Title
Severe CPT-11 toxicity in patients with Gilbert's syndrome: two case reports.
- Authors
Wasserman, E; Myara, A; Lokiec, F; Goldwasser, F; Trivin, F; Mahjoubi, M; Misset, J L; Cvitkovic, E
- Abstract
CPT-11 is hydrolyzed to its active metabolite SN-38, which is mainly eliminated through conjugation by hepatic uridine diphosphate glucuronosyl transferases (UGTs) to the glucuronide (SN-38G) derivative. Preclinical studies showed that UGT*1.1 is the isozyme responsible for SN-38 glucuronidation. Patients with Gilbert's syndrome have deficient UGT*1.1 activity, therefore may have an increased risk for related CPT-11 toxicity.
- Publication
Annals of oncology : official journal of the European Society for Medical Oncology, 1997, Vol 8, Issue 10, p1049
- ISSN
0923-7534
- Publication type
Journal Article
- DOI
10.1023/a:1008261821434