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- Title
A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.
- Authors
Surakka, Ida; Whitfield, John B; Perola, Markus; Visscher, Peter M; Montgomery, Grant W; Falchi, Mario; Willemsen, Gonneke; de Geus, Eco J C; Magnusson, Patrik K E; Christensen, Kaare; Sørensen, Thorkild I A; Pietiläinen, Kirsi H; Rantanen, Taina; Silander, Kaisa; Widén, Elisabeth; Muilu, Juha; Rahman, Iffat; Liljedahl, Ulrika; Syvänen, Ann-Christine; Palotie, Aarno; Kaprio, Jaakko; Kyvik, Kirsten O; Pedersen, Nancy L; Boomsma, Dorret I; Spector, Tim; Martin, Nicholas G; Ripatti, Samuli; Peltonen, Leena; GenomEUtwin Project
- Abstract
Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors(P=3.98 x 10-8). We followed up the association in further genotyped monozygotic twins (N= 1,261),which showed a moderate association for the variant (P= 0.200, same direction of an effect). In addition,we report a new association on the level of apolipoprotein A-ll (P= 4.03 x 1 o-8).
- Publication
Twin research and human genetics : the official journal of the International Society for Twin Studies, 2012, Vol 15, Issue 6, p691
- ISSN
1832-4274
- Publication type
Journal Article
- DOI
10.1017/thg.2012.63