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- Title
The efficacy and neurotoxicity of dexmedetomidine administered via the epidural route.
- Authors
Konakci, S; Adanir, T; Yilmaz, G; Rezanko, T
- Abstract
alpha(2)-Adrenoceptor agonists administered into the intrathecal and epidural space have been found to be effective in the treatment of chronic pain. Moreover, it was shown that they increase the analgesic effects of local anaesthetics and provide sedation, anxiolysis and haemodynamic stability. Dexmedetomidine, a potent and highly selective alpha(2)-adrenoceptor agonist, is in current clinical use, particularly in the intensive care unit. Our aim was to investigate whether dexmedetomidine produced motor and sensory blockade and neurotoxic effects when administrated via the epidural catheter in rabbits.
- Publication
European journal of anaesthesiology, 2008, Vol 25, Issue 5, p403
- ISSN
1365-2346
- Publication type
Journal Article
- DOI
10.1017/S0265021507003079