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- Title
The effect of methylphenidate and clonidine on response inhibition and state regulation in children with ADHD.
- Authors
van der Meere, J; Gunning, B; Stemerdink, N
- Abstract
The goal of this study was to evaluate the effect of methylphenidate (MPH) and clonidine in comparison with placebo on response inhibition and state regulation in children with Attention Deficit Hyperactivity Disorder (ADHD). The study utilised a double-blind cross-over design in which children were randomly assigned without replacement to placebo, MPH, and clonidine following baseline assessment. The primary dependent measures were derived from children's performance (reaction time and errors) on a GO-NO GO task under three conditions that altered the inter-stimulus interval (ISI) for presented GO-NO GO stimuli: ISI of 1 sec (fast condition), 4 sec (medium condition), and 8 sec (slow condition). Findings indicated no difference in task performance between groups treated for 7 weeks with placebo, MPH, and clonidine. We concluded that the state regulation problem in ADHD is resistant to MPH and clonidine.
- Publication
Journal of child psychology and psychiatry, and allied disciplines, 1999, Vol 40, Issue 2, p291
- ISSN
0021-9630
- Publication type
Journal Article
- DOI
10.1017/s0021963098003424