Works matching DE "CHO cell"

Results: 1286

Optimized Production of Virus-like Particles in a High-CHO-Cell-Density Transient Gene Expression System for Foot-and-Mouth Disease Vaccine Development.

Published in:

Vaccines, 2025, v. 13, n. 6, p. 581, doi. 10.3390/vaccines13060581

By:

Mignaqui, Ana Clara;
Ferella, Alejandra;
Sánchez, Cintia;
Stuible, Matthew;
Scian, Romina;
Filippi, Jorge;
Cardillo, Sabrina Beatriz;
Durocher, Yves;
Wigdorovitz, Andrés

Publication type:

Article

Ferrocene-Based Hybrid Drugs as Potential Anticancer and Antibacterial Therapeutic Agents for Incorporation into Nanocarriers: In Silico, In Vitro, Molecular Docking Evaluations.

Published in:

Pharmaceutics, 2025, v. 17, n. 6, p. 722, doi. 10.3390/pharmaceutics17060722

By:

Peter, Sijongesonke;
Morifi, Eric;
Nwamadi, Mutshinyalo;
Oselusi, Samson Olaitan;
Tantoh, Asongwe Lioniel;
Fonkui, Thierry Youmbi;
Ndinteh, Derek Tantoh;
Aderibigbe, Blessing Atim

Publication type:

Article

WAVE-based intensified perfusion cell culture for fast process development.

Published in:

Biotechnology Letters, 2023, v. 45, n. 9, p. 1117, doi. 10.1007/s10529-023-03405-8

By:

Lang, Zhe;
Yan, Shaofan;
Xiong, Qingqing;
Chen, Gong

Publication type:

Article

Low CO2 partial pressure steers CHO cells into a defective metabolic state.

Published in:

Biotechnology Letters, 2023, v. 45, n. 9, p. 1103, doi. 10.1007/s10529-023-03404-9

By:

Zhao, Liang;
Wang, Chen;
Wang, Jiaqi;
Fan, Li;
Chen, Min;
Ye, Qian;
Tan, Wen-Song

Publication type:

Article

Long term culturing of CHO cells: phenotypic drift and quality attributes of the expressed monoclonal antibody.

Published in:

Biotechnology Letters, 2023, v. 45, n. 3, p. 357, doi. 10.1007/s10529-023-03346-2

By:

Kaur, Rajinder;
Jain, Ritu;
Budholiya, Niharika;
Rathore, Anurag S.

Publication type:

Article

Novel CRISPR/Cas9-mediated knockout of LIG4 increases efficiency of site-specific integration in Chinese hamster ovary cell line.

Published in:

Biotechnology Letters, 2022, v. 44, n. 9, p. 1063, doi. 10.1007/s10529-022-03282-7

By:

Wang, Chuanjie;
Sun, Zhaolin;
Wang, Ming;
Jiang, Zhiyang;
Zhang, Mengmeng;
Cao, Hongxu;
Luo, Longlong;
Qiao, Chunxia;
Xiao, He;
Chen, Guojiang;
Li, Xinying;
Liu, Jinqing;
Wei, Zeliang;
Shen, Beifen;
Wang, Jing;
Feng, Jiannan

Publication type:

Article

Recent developments in miRNA based recombinant protein expression in CHO.

Published in:

Biotechnology Letters, 2022, v. 44, n. 5/6, p. 671, doi. 10.1007/s10529-022-03250-1

By:

Bazaz, Masoume;
Adeli, Ahmad;
Azizi, Mohammad;
Soleimani, Masoud;
Mahboudi, Fereidoun;
Davoudi, Noushin

Publication type:

Article

Differential expression of miRNAs and functional role of mir-200a in high and low productivity CHO cells expressing an Fc fusion protein.

Published in:

Biotechnology Letters, 2021, v. 43, n. 8, p. 1551, doi. 10.1007/s10529-021-03153-7

By:

Bryan, Laura;
Henry, Michael;
Barron, Niall;
Gallagher, Clair;
Kelly, Ronan M.;
Frye, Christopher C.;
Osborne, Matthew D.;
Clynes, Martin;
Meleady, Paula

Publication type:

Article

Systematically gap-filling the genome-scale metabolic model of CHO cells.

Published in:

Biotechnology Letters, 2021, v. 43, n. 1, p. 73, doi. 10.1007/s10529-020-03021-w

By:

Fouladiha, Hamideh;
Marashi, Sayed-Amir;
Li, Shangzhong;
Li, Zerong;
Masson, Helen O.;
Vaziri, Behrouz;
Lewis, Nathan E.

Publication type:

Article

LC-MS/MS-based quantitative proteomic and phosphoproteomic analysis of CHO-K1 cells adapted to growth in glutamine-free media.

Published in:

Biotechnology Letters, 2020, v. 42, n. 12, p. 2523, doi. 10.1007/s10529-020-02953-7

By:

Kaushik, Prashant;
Curell, Ricardo Valdés-Bango;
Henry, Michael;
Barron, Niall;
Meleady, Paula

Publication type:

Article

Evaluation of different IRES-mediated tricistronic plasmid designs for expression of an anti-PCSK9 biosimilar monoclonal antibody in CHO cells.

Published in:

Biotechnology Letters, 2020, v. 42, n. 12, p. 2511, doi. 10.1007/s10529-020-02952-8

By:

Cruz, Thayana A.;
Pinho, Marcos B.;
Castilho, Leda R.

Publication type:

Article

The glycosylation of anti-rhIFN-α2b recombinant antibodies influences the antigen-neutralizing activity.

Published in:

Biotechnology Letters, 2020, v. 42, n. 8, p. 1369, doi. 10.1007/s10529-020-02879-0

By:

Attallah, Carolina;
Aguilar, María Fernanda;
Forno, Guillermina;
Etcheverrigaray, Marina;
Brigido, Marcelo De Macedo;
Maranhão, Andrea Queiroz;
Oggero, Marcos

Publication type:

Article

Transposon vector-mediated stable gene transfer for the accelerated establishment of recombinant mammalian cell pools allowing for high-yield production of biologics.

Published in:

Biotechnology Letters, 2020, v. 42, n. 7, p. 1103, doi. 10.1007/s10529-020-02889-y

By:

Tschorn, Natalie;
Berg, Karen;
Stitz, Jörn

Publication type:

Article

Altered gene expression in CHO cells following polyamine starvation.

Published in:

Biotechnology Letters, 2020, v. 42, n. 6, p. 927, doi. 10.1007/s10529-020-02841-0

By:

Capella Roca, Berta;
Doolan, Padraig;
Barron, Niall;
O'Neill, Fiona;
Clynes, Martin

Publication type:

Article

A novel Xist RNA-mediated chromosome inactivation model using a mouse artificial chromosome.

Published in:

Biotechnology Letters, 2020, v. 42, n. 5, p. 697, doi. 10.1007/s10529-020-02826-z

By:

Inaoka, Daigo;
Sunamura, Naohiro;
Ohira, Takahito;
Nakayama, Yuji;
Kugoh, Hiroyuki

Publication type:

Article

Distance effect characteristic of the matrix attachment region increases recombinant protein expression in Chinese hamster ovary cells.

Published in:

Biotechnology Letters, 2020, v. 42, n. 2, p. 187, doi. 10.1007/s10529-019-02775-2

By:

Zhang, Jun-He;
Zhang, Ji-Hong;
Wang, Xiao-Yin;
Xu, Dan-Hua;
Wang, Tian-Yun

Publication type:

Article

Evaluating the impact of suramin additive on CHO cells producing Fc-fusion protein.

Published in:

Biotechnology Letters, 2019, v. 41, n. 11, p. 1255, doi. 10.1007/s10529-019-02728-9

By:

Lim, Jin-Hyuk;
Cha, Hyun-Myoung;
Han, Hye-Jin;
Kim, Dong-Il

Publication type:

Article

Optimized dual assay for the transgenes selection and screening in CHO cell line development for recombinant protein production.

Published in:

Biotechnology Letters, 2019, v. 41, n. 8/9, p. 929, doi. 10.1007/s10529-019-02711-4

By:

Beketova, Elena V.;
Ibneeva, Liliia R.;
Abdulina, Yulia A.;
Dergousova, Elena A.;
Filatov, Vladimir L.;
Kozlovsky, Stanislav V.;
Shilov, Evgeny S.;
Datskevich, Petr N.;
Rozov, Fedor N.

Publication type:

Article

Feasible development of stable HEK293 clones by CRISPR/Cas9-mediated site-specific integration for biopharmaceuticals production.

Published in:

Biotechnology Letters, 2019, v. 41, n. 8/9, p. 941, doi. 10.1007/s10529-019-02702-5

By:

Yang, Hui;
Wang, Jiaxian;
Zhao, Menglin;
Zhu, Jianwei;
Zhang, Mengxiao;
Wang, Ziyan;
Gao, Yang;
Zhu, Wen;
Lu, Huili

Publication type:

Article

Improved recombinant protein production by regulation of transcription and protein transport in Chinese hamster ovary cells.

Published in:

Biotechnology Letters, 2019, v. 41, n. 6/7, p. 719, doi. 10.1007/s10529-019-02681-7

By:

Chen, Kaiming;
Li, Dong;
Li, Hongwen;
Li, Bing;
Wang, Ruiqin;
Jiang, Lingxiao;
Huang, Lei;
Xu, Xiaoqing;
Li, Jie;
Teng, Fei;
Jiang, Cizhong;
Gu, Hua;
Fang, Jianmin

Publication type:

Article

Engineering CHO cells galactose metabolism to reduce lactate synthesis.

Published in:

Biotechnology Letters, 2019, v. 41, n. 6/7, p. 779, doi. 10.1007/s10529-019-02680-8

By:

Jiménez, N.;
Martínez, V. S.;
Gerdtzen, Z. P.

Publication type:

Article

Human genome-derived TOP1 matrix attachment region enhances transgene expression in the transfected CHO cells.

Published in:

Biotechnology Letters, 2019, v. 41, n. 6/7, p. 701, doi. 10.1007/s10529-019-02673-7

By:

Jia, Yan-Long;
Guo, Xiao;
Wang, Xi-Cheng;
Wang, Tian-Yun

Publication type:

Article

Chromatographic purification of recombinant human erythropoietin.

Published in:

Biotechnology Letters, 2019, v. 41, n. 4/5, p. 483, doi. 10.1007/s10529-019-02656-8

By:

Adamíková, Jana;
Antošová, Monika;
Polakovič, Milan

Publication type:

Article

Cell culture medium supplemented with taurine decreases basic charge variant levels of a monoclonal antibody.

Published in:

Biotechnology Letters, 2018, v. 40, n. 11/12, p. 1487, doi. 10.1007/s10529-018-2606-4

By:

Liu, Mengjuan;
Wang, Jiaqi;
Tang, Hongping;
Fan, Li;
Zhao, Liang;
Wang, Hai-Bin;
Zhou, Yan;
Tan, Wen-Song

Publication type:

Article

Stable expression of infliximab in CRISPR/Cas9-mediated BAK1-deficient CHO cells.

Published in:

Biotechnology Letters, 2018, v. 40, n. 8, p. 1209, doi. 10.1007/s10529-018-2578-4

By:

Miao, Zhi;
Li, Qian;
Zhao, Jian;
Wang, Peng;
Wang, Lei;
He, Hong-Peng;
Wang, Nan;
Zhou, Hao;
Zhang, Tong-Cun;
Luo, Xue-Gang

Publication type:

Article

A simple method to determine IgG light chain to heavy chain polypeptide ratios expressed by CHO cells.

Published in:

Biotechnology Letters, 2016, v. 38, n. 12, p. 2043, doi. 10.1007/s10529-016-2197-x

By:

Gerster, Anja;
Wodarczyk, Claas;
Reichenbächer, Britta;
Köhler, Janet;
Schulze, Andreas;
Krause, Felix;
Müller, Dethardt

Publication type:

Article

Correlative Electron Microscopy and NanoSIMS Analysis for Lipid Studies.

Published in:

Microscopy & Microanalysis, 2019, p. 360, doi. 10.1017/S1431927618002295

By:

Jiang, Haibo;
He, Cuiwen;
Fong, Loren;
Young, Stephen

Publication type:

Article

Isolation and purification of a monoclonal antibody from a cell culture supernatant by multistage precipitation and solid-liquid extraction.

Published in:

Food & Bioproducts Processing: Transactions of the Institution of Chemical Engineers Part C, 2024, v. 147, p. 34, doi. 10.1016/j.fbp.2024.05.016

By:

Rumanek, Tomasz;
Kolodziej, Michal;
Piqtkowski, Wojciech;
Antos, Dorota

Publication type:

Article

Optimal culture medium selection and supplementation for recombinant thaumatin II production by Komagataella phaffii.

Published in:

Food & Bioproducts Processing: Transactions of the Institution of Chemical Engineers Part C, 2023, v. 139, p. 190, doi. 10.1016/j.fbp.2023.04.001

By:

Joseph, Jewel Ann;
Akkermans, Simen;
Cornillie, Elke;
Deberlanger, Jerome;
Van Impe, Jan F. M.

Publication type:

Article

Expression and bioactivity of recombinant human serum albumin and dTMP fusion proteins in CHO cells.

Published in:

Applied Microbiology & Biotechnology, 2016, v. 100, n. 17, p. 7565, doi. 10.1007/s00253-016-7447-2

By:

Ru, Yi;
Zhi, Dejuan;
Guo, Dingding;
Wang, Yong;
Li, Yang;
Wang, Meizhu;
Wei, Suzhen;
Wang, Haiqing;
Wang, Na;
Che, Jingmin;
Li, Hongyu

Publication type:

Article

A control strategy to investigate the relationship between specific productivity and high-mannose glycoforms in CHO cells.

Published in:

Applied Microbiology & Biotechnology, 2016, v. 100, n. 16, p. 7011, doi. 10.1007/s00253-016-7380-4

By:

Zalai, Dénes;
Hevér, Helga;
Lovász, Krisztina;
Molnár, Dóra;
Wechselberger, Patrick;
Hofer, Alexandra;
Párta, László;
Putics, Ákos;
Herwig, Christoph

Publication type:

Article

Regulation of cell growth and apoptosis through lactate dehydrogenase C over-expression in Chinese hamster ovary cells.

Published in:

Applied Microbiology & Biotechnology, 2016, v. 100, n. 11, p. 5007, doi. 10.1007/s00253-016-7348-4

By:

Fu, Tuo;
Zhang, Cunchao;
Jing, Yu;
Jiang, Cheng;
Li, Zhenhua;
Wang, Shengyu;
Ma, Kai;
Zhang, Dapeng;
Hou, Sheng;
Dai, Jianxin;
Kou, Geng;
Wang, Hao

Publication type:

Article

High zinc ion supplementation of more than 30 μM can increase monoclonal antibody production in recombinant Chinese hamster ovary DG44 cell culture.

Published in:

Applied Microbiology & Biotechnology, 2016, v. 100, n. 5, p. 2163, doi. 10.1007/s00253-015-7096-x

By:

Kim, Bong;
Park, Hong

Publication type:

Article

Understanding the intracellular effects of yeast extract on the enhancement of Fc-fusion protein production in Chinese hamster ovary cell culture.

Published in:

Applied Microbiology & Biotechnology, 2015, v. 99, n. 20, p. 8429, doi. 10.1007/s00253-015-6789-5

By:

Hu, Dongdong;
Sun, Yating;
Liu, Xuping;
Liu, Jintao;
Zhang, Xintao;
Zhao, Liang;
Wang, Haibin;
Tan, Wen-Song;
Fan, Li

Publication type:

Article

Elucidating the effects of arginine and lysine on a monoclonal antibody C-terminal lysine variation in CHO cell cultures.

Published in:

Applied Microbiology & Biotechnology, 2015, v. 99, n. 16, p. 6643, doi. 10.1007/s00253-015-6617-y

By:

Zhang, Xintao;
Tang, Hongping;
Sun, Ya-Ting;
Liu, Xuping;
Tan, Wen-Song;
Fan, Li

Publication type:

Article

Benchmarking of commercially available CHO cell culture media for antibody production.

Published in:

Applied Microbiology & Biotechnology, 2015, v. 99, n. 11, p. 4645, doi. 10.1007/s00253-015-6514-4

By:

Reinhart, David;
Damjanovic, Lukas;
Kaisermayer, Christian;
Kunert, Renate

Publication type:

Article

In search of expression bottlenecks in recombinant CHO cell lines-a case study.

Published in:

Applied Microbiology & Biotechnology, 2014, v. 98, n. 13, p. 5959, doi. 10.1007/s00253-014-5584-z

By:

Reinhart, David;
Sommeregger, Wolfgang;
Debreczeny, Monika;
Gludovacz, Elisabeth;
Kunert, Renate

Publication type:

Article

Enhancement of recombinant human EPO production and glycosylation in serum-free suspension culture of CHO cells through expression and supplementation of 30Kc19.

Published in:

Applied Microbiology & Biotechnology, 2012, v. 96, n. 3, p. 671, doi. 10.1007/s00253-012-4203-0

By:

Park, Ju;
Wang, Zesong;
Jeong, Hee-Jin;
Park, Hee;
Kim, Byung-Gee;
Tan, Wen-Song;
Choi, Shin;
Park, Tai

Publication type:

Article

Erratum to: Insight into the roles of hypoxanthine and thymidine on cultivating antibody-producing CHO cells: cell growth, antibody production and long-term stability.

Published in:

2012

By:

Chen, Fei;
Fan, Li;
Wang, Jiaqi;
Zhou, Yan;
Ye, Zhaoyang;
Zhao, Liang;
Tan, Wen-Song

Publication type:

Correction Notice

The absence of effect of gene copy number and mRNA level on the amount of mAb secretion from mammalian cells.

Published in:

Applied Microbiology & Biotechnology, 2008, v. 81, n. 4, p. 701, doi. 10.1007/s00253-008-1701-1

By:

Reisinger, Hannes;
Steinfellner, Willibald;
Stern, Beate;
Katinger, Hermann;
Kunert, Renate

Publication type:

Article

The role of Bcl-2 and its combined effect with p21CIP1 in adaptation of CHO cells to suspension and protein-free culture.

Published in:

Applied Microbiology & Biotechnology, 2008, v. 78, n. 3, p. 391, doi. 10.1007/s00253-007-1320-2

By:

Astley, Kelly;
Al-Rubeai, Mohamed

Publication type:

Article

Human diamine oxidase cellular binding and internalization in vitro and rapid clearance in vivo are not mediated by N-glycans but by heparan sulfate proteoglycan interactions.

Published in:

Glycobiology, 2021, v. 31, n. 4, p. 444, doi. 10.1093/glycob/cwaa090

By:

Gludovacz, Elisabeth;
Schuetzenberger, Kornelia;
Resch, Marlene;
Tillmann, Katharina;
Petroczi, Karin;
Vondra, Sigrid;
Vakal, Serhii;
Schosserer, Markus;
Virgolini, Nikolaus;
Pollheimer, Jürgen;
Salminen, Tiina A;
Jilma, Bernd;
Borth, Nicole;
Boehm, Thomas

Publication type:

Article

Engineering mammalian cells to produce plant-specific N-glycosylation on proteins.

Published in:

Glycobiology, 2020, v. 30, n. 8, p. 528, doi. 10.1093/glycob/cwaa009

By:

Larsen, Joachim Steen;
Karlsson, Richard Torbjörn Gustav;
Tian, Weihua;
Schulz, Morten Alder;
Matthes, Annemarie;
Clausen, Henrik;
Petersen, Bent Larsen;
Yang, Zhang

Publication type:

Article

Polysialic acid is expressed in human naïve CD4+ T cells and is involved in modulating activation.

Published in:

Glycobiology, 2019, v. 29, n. 7, p. 557, doi. 10.1093/glycob/cwz032

By:

Villanueva-Cabello, Tania M;
Gutiérrez-Valenzuela, Lya D;
López-Guerrero, Delia V;
Cruz-Muñoz, Mario E;
Mora-Montes, Héctor M;
Martínez-Duncker, Iván

Publication type:

Article

Process intensification at the expression system level for the production of 1-phosphate aldolase in antibiotic-free E. coli fed-batch cultures.

Published in:

Journal of Industrial Microbiology & Biotechnology, 2022, v. 49, n. 4, p. 1, doi. 10.1093/jimb/kuac018

By:

Pasini, Martina;
Fernández-Castané, Alfred;
Caminal, Gloria;
Overton, Tim W;
Ferrer, Pau

Publication type:

Article

Process intensification at the expression system level for the production of 1-phosphate aldolase in antibiotic-free E. coli fed-batch cultures.

Published in:

Journal of Industrial Microbiology & Biotechnology, 2022, v. 49, n. 3, p. 1, doi. 10.1093/jimb/kuac018

By:

Pasini, Martina;
Fernández-Castané, Alfred;
Caminal, Gloria;
Overton, Tim W;
Ferrer, Pau

Publication type:

Article

A novel method based on nonparametric regression with a Gaussian kernel algorithm identifies the critical components in CHO media and feed optimization.

Published in:

Journal of Industrial Microbiology & Biotechnology, 2020, v. 47, n. 1, p. 63, doi. 10.1007/s10295-019-02248-5

By:

Zou, Mao;
Zhou, Zi-Wei;
Fan, Li;
Zhang, Wei-Jian;
Zhao, Liang;
Liu, Xu-Ping;
Wang, Hai-Bin;
Tan, Wen-Song

Publication type:

Article

Impact of mammalian cell culture conditions on monoclonal antibody charge heterogeneity: an accessory monitoring tool for process development.

Published in:

Journal of Industrial Microbiology & Biotechnology, 2019, v. 46, n. 8, p. 1167, doi. 10.1007/s10295-019-02202-5

By:

Sissolak, Bernhard;
Lingg, Nico;
Sommeregger, Wolfgang;
Striedner, Gerald;
Vorauer-Uhl, Karola

Publication type:

Article

IP3R at ER-Mitochondrial Contact Sites: Beyond the IP3R-GRP75-VDAC1 Ca2+ Funnel.

Published in:

Contact (25152564), 2023, v. 6, p. 1, doi. 10.1177/25152564231181020

By:

Atakpa-Adaji, Peace;
Ivanova, Adelina

Publication type:

Article

稳定表达猪 δ 冠状病毒 S1 蛋白 CHO 细胞系的构建与鉴定.

Published in:

Journal of Henan Agricultural Sciences, 2023, v. 52, n. 6, p. 131, doi. 10.15933/j.cnki.1004‐3268.2023.06.014

By:

孙雪珂;
丁培阳;
王思桥;
刘思源;
李明慧;
常泽杰;
陈艺兰;
李瑞琪;
张改平

Publication type:

Article