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- Title
Selective β<sub>1</sub>-blockade attenuates post-infarct remodelling without improvement in myocardial energy metabolism and function in rats with heart failure
- Authors
Omerovic, E.; Bollano, E.; Soussi, B.; Waagstein, F.
- Abstract
Objective: To investigate in vivo effects of long-term selective β1-blockade on cardiac energy metabolism, remodelling, function and plasma cytokines in a rat model of post-infarct congestive heart failure (CHF). Methods: Myocardial infarction (MI) was induced in male rats by ligation of the left coronary artery. Three different groups of rats were studied, MI rats treated with metoprolol (n=17), MI rats treated with saline (n=14) and sham-operated rats (n=12). The treatment with metoprolol 1 mg/kg/h was initiated in the third week post-infarct for a period of 6 weeks. All rats were investigated non-invasively with volume-selective 31P magnetic resonance spectroscopy and echocardiography for evaluation of left ventricular (LV) energy metabolism, morphology and function. Plasma concentration of IL-1β and IL-6 and density of β-adrenergic receptors were analyzed. Results: Metoprolol attenuated the increase in LV dimensions and volumes. Treatment with metoprolol had no effect on PCr/ATP and LV function. Plasma level of IL-1β was higher and IL-6 was lower in the metoprolol group. Density of β-adrenergic receptors was similar in all three groups. Conclusion: Selective β1-blockade in rats with chronic CHF attenuates post-infarct structural remodelling, without concomitant improvement in myocardial energy metabolism and function. Improvements in myocardial energy metabolism and function do not precede and are not a prerequisite for an anti-remodelling effect of β1-blockade in the setting of chronic CHF.
- Publication
European Journal of Heart Failure, 2003, Vol 5, Issue 6, p725
- ISSN
1388-9842
- Publication type
Academic Journal
- DOI
10.1016/S1388-9842(03)00153-3