We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
[Activity of anidulafungin against Candida biofilms].
- Authors
Pemán, Javier; Cantón, Emilia; Valentín, Amparo
- Abstract
Currently, no standardized method to study the in vitro activity of antifungal agents on biofilms is available, thus, the comparison among different authors is difficult. The studies discussed in this review use the XTT reduction to measure the activity of antifungals on biofilms of 24 h of maturation. To date, biofilm anidulafungin MICs of 47 isolates of Candida spp. (25 Candida albicans, 16 Candida tropicalis, 5 Candida dubliniensis and 1 Candida parapsilosis) have been published. The geometric mean MIC of anidulafungin on biofilms of Candida spp. is of 1.18 microg/ml. Against isolates of species with great capacity of biofilm formation, the geometric mean MIC is 0.325 (C. albicans), 2 (C. parapsilosis) and 0.5 microg/ml (C. dubliniensis). No echinocandin has activity on C. tropicalis biofilms. In addition, anidulafungin can be used for lock therapy of catheters since it is the echinocandin with the least in vitro paradoxical effect.
- Publication
Revista iberoamericana de micologia, 2008, Vol 25, Issue 2, p124
- ISSN
1130-1406
- Publication type
Journal Article
- DOI
10.1016/s1130-1406(08)70030-5