We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Minor H antigens: genes and peptides.
- Authors
Simpson, E; Scott, D; James, E; Lombardi, G; Cwynarski, K; Dazzi, F; Millrain, M; Dyson, P J
- Abstract
In this review, we describe the evidence from which the existence of non-MHC histocompatibility (H) antigens was deduced, the clinical setting of bone marrow transplantation in which they are important targets for T cell responses, and the current understanding of their molecular identity. We list the peptide epitopes, their MHC restriction molecules and the genes encoding them, of the human and murine minor H antigens now identified at the molecular level. Identification of the peptide epitopes allows T cell responses to these antigens following transplantation of MHC-matched, minor H-mismatched tissues to be enumerated using tetramers and elispot assays. This will facilitate analysis of correlations with HVG, GVH and GVL reactions in vivo. The potential to use minor H peptides to modulate in vivo responses to minor H antigens is discussed. Factors controlling immunodominance of T cell responses to one or a few of many potential minor H antigens remain to be elucidated but are important for making predictions of in vivo HVG, GVH and GVL responses and tailoring therapy after HLA-matched BMT and DLI.
- Publication
Transplant immunology, 2002, Vol 10, Issue 2-3, p115
- ISSN
0966-3274
- Publication type
Journal Article
- DOI
10.1016/s0966-3274(02)00057-6