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- Title
Investigation of variant Creutzfeldt-Jakob disease and other human prion diseases with tonsil biopsy samples.
- Authors
Hill, A F; Butterworth, R J; Joiner, S; Jackson, G; Rossor, M N; Thomas, D J; Frosh, A; Tolley, N; Bell, J E; Spencer, M; King, A; Al-Sarraj, S; Ironside, J W; Lantos, P L; Collinge, J
- Abstract
Prion diseases are associated with the accumulation of an abnormal isoform of cellular prion protein (PrPSc), which is the principal constituent of prions. Prions replicate in lymphoreticular tissues before neuroinvasion, suggesting that lymphoreticular biopsy samples may allow early diagnosis by detection of PrPSc. Variant Creutzfeldt-Jakob disease (variant CJD) is difficult to distinguish from common psychiatric disorders in its early stages and definitive diagnosis has relied on neuropathology. We studied lymphoreticular tissues from a necropsy series and assessed tonsillar biopsy samples as a diagnostic investigation for human prion disease.
- Publication
Lancet (London, England), 1999, Vol 353, Issue 9148, p183
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/s0140-6736(98)12075-5