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- Title
Association of variants of the gene for mannose-binding lectin with susceptibility to meningococcal disease. Meningococcal Research Group.
- Authors
Hibberd, M L; Sumiya, M; Summerfield, J A; Booy, R; Levin, M
- Abstract
The reasons why meningococcal disease develops in only a small proportion of individuals carrying the causative bacteria are unknown. Differences in host responses to bacterial colonisation are thought to be involved, since people with deficiencies in the terminal components of the complement pathway, or of properdin, are susceptible to meningococcal disease. We postulate that genetic variants of mannose-binding lectin (MBL), a plasma opsonin that initiates another pathway of complement activation, might similarly cause susceptibility to meningococcal disease.
- Publication
Lancet (London, England), 1999, Vol 353, Issue 9158, p1049
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/s0140-6736(98)08350-0