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Title
Frequency and prognostic significance of isolated tumour cells in bone marrow of patients with non-small-cell lung cancer without overt metastases.
Authors
Pantel, K; Izbicki, J; Passlick, B; Angstwurm, M; Häussinger, K; Thetter, O; Riethmüller, G
Abstract
Metastasis is generally looked on as a late event in the natural history of epithelial tumours. However, the poor prognosis of patients with apparently localised lung cancer indicates that micrometastases occur often before diagnosis of the primary tumour.