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- Title
Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)
- Authors
Stephens, N G; Parsons, A; Schofield, P M; Kelly, F; Cheeseman, K; Mitchinson, M J
- Abstract
Vitamin E (alpha-tocopherol) is thought to have a role in prevention of atherosclerosis, through inhibition of oxidation of low-density lipoprotein. Some epidemiological studies have shown an association between high dietary intake or high serum concentrations of alpha-tocopherol and lower rates of ischaemic heart disease. We tested the hypothesis that treatment with a high dose of alpha-tocopherol would reduce subsequent risk of myocardial infarction (MI) and cardiovascular death in patients with established ischaemic heart disease.
- Publication
Lancet (London, England), 1996, Vol 347, Issue 9004, p781
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/s0140-6736(96)90866-1