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- Title
Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-naïve patients.
- Authors
Andreasen, N C; O'Leary, D S; Flaum, M; Nopoulos, P; Watkins, G L; Boles Ponto, L L; Hichwa, R D
- Abstract
There have been reports that patients with schizophrenia have decreased metabolic activity in prefrontal cortex. However, findings have been confounded by medication effects, chronic illness, and difficulties of measurement. We aimed to address these problems by examination of cerebral blood flow with positron emission tomography (PET).
- Publication
Lancet (London, England), 1997, Vol 349, Issue 9067, p1730
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/s0140-6736(96)08258-x