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- Title
Randomised double-blind placebo-controlled study of the effect of inhibition of nitric oxide synthesis in bradykinin-induced asthma.
- Authors
Ricciardolo, F L; Geppetti, P; Mistretta, A; Nadel, J A; Sapienza, M A; Bellofiore, S; Di Maria, G U
- Abstract
Bronchoconstriction induced by bradykinin is reduced by the release of nitric oxide (NO) in the airways of guinea pigs. Inhaled NO is known to cause bronchodilatation in asthmatic patients. To find out the role of endogenous NO in airway response to bradykinin in asthma, we examined the effect of the NO synthase inhibitor NG-monomethyl-L-arginine (L-NMMA) on broncho-constriction after bradykinin challenge in ten patients with mild asthma.
- Publication
Lancet (London, England), 1996, Vol 348, Issue 9024, p374
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/s0140-6736(96)04450-9