We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Bronchoprotective role for endogenous prostaglandin E2.
- Authors
Pavord, I D; Tattersfield, A E
- Abstract
The possibility that impaired production of bronchoprotective factors contributes to the pathogenesis of asthma cannot be excluded. Prostaglandin E2 (PGE2) could be such a factor. It is a dominant cyclo-oxygenase product of airway epithelium and smooth muscle; it has inhibitory effects on inflammatory cells and pathways involved in bronchoconstriction at concentrations known to occur in the airway; inhalation of PGE2 has considerable bronchoprotective effects in patients with asthma; and manoeuvres that increase or decrease endogenous production of PGE2 have beneficial and deleterious effects on airway function.
- Publication
Lancet (London, England), 1995, Vol 345, Issue 8947, p436
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/s0140-6736(95)90409-3