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- Title
Mother-to-infant transmission of hepatitis C virus. Lombardy Study Group on Vertical HCV Transmission.
- Authors
Zanetti, A R; Tanzi, E; Paccagnini, S; Principi, N; Pizzocolo, G; Caccamo, M L; D'Amico, E; Cambiè, G; Vecchi, L
- Abstract
To assess the risk of mother-to-infant transmission of hepatitis C virus (HCV), we followed up 116 babies of anti-HCV positive mothers, of whom 22 were coinfected with HIV and 94 had HCV alone. None of the babies whose mothers had HCV alone acquired HCV, while 8 babies (36%; p < 0.001) of mothers co-infected with HIV acquired HCV (5 babies) or HCV and HIV (3). There was no association between any specific maternal HCV genotype and enhanced risk of neonatal infection. HCV-RNA levels were significantly higher (p < 0.05) in mothers with HIV coinfection than in those with HCV alone. These data indicate that maternal HIV status correlates with enhanced level of viraemia which favours neonatal infection.
- Publication
Lancet (London, England), 1995, Vol 345, Issue 8945, p289
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/s0140-6736(95)90277-5