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- Title
Angiotensin-converting-enzyme inhibitors in stable vascular disease without left ventricular systolic dysfunction or heart failure: a combined analysis of three trials.
- Authors
Dagenais, Gilles R; Pogue, Janice; Fox, Kim; Simoons, Marteen L; Yusuf, Salim
- Abstract
Angiotensin-converting-enzyme (ACE) inhibitors reduce cardiovascular mortality and morbidity in patients with heart failure or left ventricular systolic dysfunction (LVSD). Three large trials have assessed the effect of ACE inhibitors in stable patients without these conditions but with atherosclerosis. We undertook a systematic review of the Heart Outcomes Prevention Evaluation (HOPE), the European trial on Reduction Of cardiac events with Perindopril among patients with stable coronary Artery disease (EUROPA), and the Prevention of Events with ACE inhibition (PEACE) studies to determine the consistency with which ACE inhibitors reduce total mortality and fatal and non-fatal cardiovascular events.
- Publication
Lancet (London, England), 2006, Vol 368, Issue 9535, p581
- ISSN
1474-547X
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(06)69201-5