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- Title
Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison.
- Authors
Smithuis, Frank; Kyaw, Moe Kyaw; Phe, Ohn; Aye, Khin Zarli; Htet, Linn; Barends, Marion; Lindegardh, Niklas; Singtoroj, Thida; Ashley, Elizabeth; Lwin, Saw; Stepniewska, Kasia; White, Nicholas J
- Abstract
Artemisinin-based combinations are judged the best treatments for multidrug-resistant Plasmodium falciparum malaria. Artesunate-mefloquine is widely recommended in southeast Asia, but its high cost and tolerability profile remain obstacles to widespread deployment. To assess whether dihydroartemisinin-piperaquine is a suitable alternative to artesunate-mefloquine, we compared the safety, tolerability, efficacy, and effectiveness of the two regimens for the treatment of uncomplicated falciparum in western Myanmar (Burma).
- Publication
Lancet (London, England), 2006, Vol 367, Issue 9528, p2075
- ISSN
1474-547X
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(06)68931-9