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- Title
Development of adenoviral-vector-based pandemic influenza vaccine against antigenically distinct human H5N1 strains in mice.
- Authors
Hoelscher, Mary A; Garg, Sanjay; Bangari, Dinesh S; Belser, Jessica A; Lu, Xiuhua; Stephenson, Iain; Bright, Rick A; Katz, Jacqueline M; Mittal, Suresh K; Sambhara, Suryaprakash
- Abstract
Avian H5N1 influenza viruses currently circulating in southeast Asia could potentially cause the next pandemic. However, currently licensed human vaccines are subtype-specific and do not protect against these H5N1 viruses. We aimed to develop an influenza vaccine and assessed its immunogenicity and efficacy to confer protection in BALB/c mice.
- Publication
Lancet (London, England), 2006, Vol 367, Issue 9509, p475
- ISSN
1474-547X
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(06)68076-8