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- Title
Banking on human embryonic stem cells: estimating the number of donor cell lines needed for HLA matching.
- Authors
Taylor, Craig J; Bolton, Eleanor M; Pocock, Susan; Sharples, Linda D; Pedersen, Roger A; Bradley, J Andrew
- Abstract
Human embryonic stem (hES) cells are a promising source for transplantation to replace diseased or damaged tissue, but their differentiated progeny express human leucocyte antigens (HLAs) that will probably cause graft rejection. The creation of a bank of HLA-typed hES cells, from which a best match could be selected, would help reduce the likelihood of graft rejection. We investigated how many hES cell lines would be needed to make matching possible in most cases.
- Publication
Lancet (London, England), 2005, Vol 366, Issue 9502, p2019
- ISSN
1474-547X
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(05)67813-0