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- Title
NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses.
- Authors
García-Closas, Montserrat; Malats, Núria; Silverman, Debra; Dosemeci, Mustafa; Kogevinas, Manolis; Hein, David W; Tardón, Adonina; Serra, Consol; Carrato, Alfredo; García-Closas, Reina; Lloreta, Josep; Castaño-Vinyals, Gemma; Yeager, Meredith; Welch, Robert; Chanock, Stephen; Chatterjee, Nilanjan; Wacholder, Sholom; Samanic, Claudine; Torà, Montserrat; Fernández, Francisco; Real, Francisco X; Rothman, Nathaniel
- Abstract
Many reported associations between common genetic polymorphisms and complex diseases have not been confirmed in subsequent studies. An exception could be the association between NAT2 slow acetylation, GSTM1 null genotype, and bladder-cancer risk. However, current evidence is based on meta-analyses of relatively small studies (range 23-374 cases) with some evidence of publication bias and study heterogeneity. Associations between polymorphisms in other NAT and GST genes and bladder-cancer risk have been inconsistent.
- Publication
Lancet (London, England), 2005, Vol 366, Issue 9486, p649
- ISSN
1474-547X
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(05)67137-1