We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Depletion of latent HIV-1 infection in vivo: a proof-of-concept study.
- Authors
Lehrman, Ginger; Hogue, Ian B; Palmer, Sarah; Jennings, Cheryl; Spina, Celsa A; Wiegand, Ann; Landay, Alan L; Coombs, Robert W; Richman, Douglas D; Mellors, John W; Coffin, John M; Bosch, Ronald J; Margolis, David M
- Abstract
Persistent infection in resting CD4+ T cells prevents eradication of HIV-1. Since the chromatin remodeling enzyme histone deacetylase 1 (HDAC1) maintains latency of integrated HIV, we tested the ability of the HDAC inhibitor valproic acid to deplete persistent, latent infection in resting CD4+ T cells.
- Publication
Lancet (London, England), 2005, Vol 366, Issue 9485, p549
- ISSN
1474-547X
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(05)67098-5