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- Title
The metabolic syndrome.
- Authors
Eckel, Robert H; Grundy, Scott M; Zimmet, Paul Z
- Abstract
The metabolic syndrome is a common metabolic disorder that results from the increasing prevalence of obesity. The disorder is defined in various ways, but in the near future a new definition(s) will be applicable worldwide. The pathophysiology seems to be largely attributable to insulin resistance with excessive flux of fatty acids implicated. A proinflammatory state probably contributes to the syndrome. The increased risk for type 2 diabetes and cardiovascular disease demands therapeutic attention for those at high risk. The fundamental approach is weight reduction and increased physical activity; however, drug treatment could be appropriate for diabetes and cardiovascular disease risk reduction.
- Publication
Lancet (London, England), 2005, Vol 365, Issue 9468, p1415
- ISSN
1474-547X
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(05)66378-7