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- Title
The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes.
- Authors
Gillespie, Kathleen M; Bain, Steven C; Barnett, Anthony H; Bingley, Polly J; Christie, Michael R; Gill, Geoffrey V; Gale, Edwin A M
- Abstract
The incidence of childhood type 1 diabetes has risen over the past 50 years. We compared the frequency of HLA class II haplotypes in 194 patients diagnosed more than 50 years ago and 582 age-matched and sex-matched individuals diagnosed between 1985 and 2002. The proportion of high-risk susceptibility genotypes was increased in the earlier cohort (p=0.003), especially in those diagnosed at age 5 years or younger, which is consistent with the hypothesis that the rise of type 1 diabetes is due to a major environmental effect.
- Publication
Lancet (London, England), 2004, Vol 364, Issue 9446, p1699
- ISSN
1474-547X
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(04)17357-1