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- Title
Effectiveness of meningococcal serogroup C conjugate vaccine 4 years after introduction.
- Authors
Trotter, Caroline L; Andrews, Nick J; Kaczmarski, Edward B; Miller, Elizabeth; Ramsay, Mary E
- Abstract
The meningococcal serogroup C conjugate (MCC) vaccine programme in England has successfully controlled the incidence of serogroup C disease, as a result of high short-term vaccine effectiveness and substantial herd immunity. However, the long-term effectiveness of the vaccine remains unknown. We assessed surveillance data from the 4 years since introduction of the programme. Vaccine effectiveness remained high in children vaccinated in the catch-up campaign (aged 5 months to 18 years). However, for children vaccinated in the routine infant immunisation programme, the effectiveness of the MCC vaccine fell to low levels after only 1 year. The number of individuals in these cohorts remains low, but alternative routine immunisation schedules should be considered to ensure high levels of protection are sustained.
- Publication
Lancet (London, England), 2004, Vol 364, Issue 9431, p365
- ISSN
1474-547X
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(04)16725-1