We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Stem-cell therapy for diabetes mellitus.
- Authors
Hussain, Mehboob A; Theise, Neil D
- Abstract
Curative therapy for diabetes mellitus mainly implies replacement of functional insulin-producing pancreatic beta cells, with pancreas or islet-cell transplants. However, shortage of donor organs spurs research into alternative means of generating beta cells from islet expansion, encapsulated islet xenografts, human islet cell-lines, and stem cells. Stem-cell therapy here implies the replacement of diseased or lost cells from progeny of pluripotent or multipotent cells. Both embryonic stem cells (derived from the inner cell mass of a blastocyst) and adult stem cells (found in the postnatal organism) have been used to generate surrogate beta cells or otherwise restore beta-cell functioning.
- Publication
Lancet (London, England), 2004, Vol 364, Issue 9429, p203
- ISSN
1474-547X
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(04)16635-X