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- Title
Male circumcision and risk of HIV-1 and other sexually transmitted infections in India.
- Authors
Reynolds, Steven J; Shepherd, Mary E; Risbud, Arun R; Gangakhedkar, Raman R; Brookmeyer, Ronald S; Divekar, Anand D; Mehendale, Sanjay M; Bollinger, Robert C
- Abstract
Circumcised men have a lower risk of HIV-1 infection than uncircumcised men. Laboratory findings suggest that the foreskin is enriched with HIV-1 target cells. However, some data suggest that circumcision could simply be a marker for low-risk behaviours. In a prospective study of 2298 HIV-uninfected men attending sexually transmitted infection clinics in India, we noted that circumcision was strongly protective against HIV-1 infection (adjusted relative risk 0.15; 95% CI 0.04-0.62; p=0.0089); however, we noted no protective effect against herpes simplex virus type 2, syphilis, or gonorrhoea. The specificity of this relation suggests a biological rather than behavioural explanation for the protective effect of male circumcision against HIV-1.
- Publication
Lancet (London, England), 2004, Vol 363, Issue 9414, p1039
- ISSN
1474-547X
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(04)15840-6