We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Programmes and principles in treatment of multidrug-resistant tuberculosis.
- Authors
Mukherjee, Joia S; Rich, Michael L; Socci, Adrienne R; Joseph, J Keith; Virú, Felix Alcántara; Shin, Sonya S; Furin, Jennifer J; Becerra, Mercedes C; Barry, Donna J; Kim, Jim Yong; Bayona, Jaime; Farmer, Paul; Smith Fawzi, Mary C; Seung, Kwonjune J
- Abstract
Multidrug-resistant tuberculosis (MDR-TB) presents an increasing threat to global tuberculosis control. Many crucial management issues in MDR-TB treatment remain unanswered. We reviewed the existing scientific research on MDR-TB treatment, which consists entirely of retrospective cohort studies. Although direct comparisons of these studies are impossible, some insights can be gained: MDR-TB can and should be addressed therapeutically in resource-poor settings; starting of treatment early is crucial; aggressive treatment regimens and high-end dosing are recommended given the lower potency of second-line antituberculosis drugs; and strategies to improve treatment adherence, such as directly observed therapy, should be used. Opportunities to treat MDR-TB in developing countries are now possible through the Global Fund to Fight AIDS, TB, and Malaria, and the Green Light Committee for Access to Second-line Anti-tuberculosis Drugs. As treatment of MDR-TB becomes increasingly available in resource-poor areas, where it is needed most, further clinical and operational research is urgently needed to guide clinicians in the management of this disease.
- Publication
Lancet (London, England), 2004, Vol 363, Issue 9407, p474
- ISSN
1474-547X
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(04)15496-2