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- Title
Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong.
- Authors
Chim, S S C; Tsui, S K W; Chan, K C A; Au, T C C; Hung, E C W; Tong, Y K; Chiu, R W K; Ng, E K O; Chan, P K S; Chu, C M; Sung, J J Y; Tam, J S; Fung, K P; Waye, M M Y; Lee, C Y; Yuen, K Y; Lo, Y M D; CUHK Molecular SARS Research Group
- Abstract
Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the importance of non-viral genomic factors in this outbreak.
- Publication
Lancet (London, England), 2003, Vol 362, Issue 9398, p1807
- ISSN
1474-547X
- Publication type
Journal Article
- DOI
10.1016/s0140-6736(03)14901-x