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- Title
Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial.
- Authors
Granger, Christopher B; McMurray, John J V; Yusuf, Salim; Held, Peter; Michelson, Eric L; Olofsson, Bertil; Ostergren, Jan; Pfeffer, Marc A; Swedberg, Karl; CHARM Investigators and Committees
- Abstract
Angiotensin-converting-enzyme (ACE) inhibitors improve outcome of patients with chronic heart failure (CHF). A substantial proportion of patients, however, experience no benefit from ACE inhibitors because of previous intolerance. We aimed to find out whether candesartan, an angiotensin-receptor blocker, could improve outcome in such patients not taking an ACE inhibitor.
- Publication
Lancet (London, England), 2003, Vol 362, Issue 9386, p772
- ISSN
1474-547X
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(03)14284-5