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- Title
Are imprecise methods obscuring a relation between fat and breast cancer?
- Authors
Bingham, Sheila A; Luben, Robert; Welch, Ailsa; Wareham, Nicholas; Khaw, Kay-Tee; Day, Nicholas
- Abstract
Pooled analyses of cohort studies show no relation between fat intake and breast-cancer risk. However, food-frequency questionnaire (FFQ) methods used in these studies are prone to measurement error. We assessed diet with an FFQ and a detailed 7-day food diary in 13070 women between 1993 and 1997. We compared 168 breast-cancer cases incident by 2000 with four matched controls. Risk of breast cancer was associated with saturated-fat intake measured with the food diary (hazard ratio 1.22 [95% CI 1.06-1.40], p=0.005, per quintile increase in energy-adjusted fat intake), but not with saturated fat measured with the FFQ (1.10 [0.94-1.29], p=0.23). Dietary measurement error might explain the absence of a significant association between dietary fat and breast-cancer risk in cohort studies.
- Publication
Lancet (London, England), 2003, Vol 362, Issue 9379, p212
- ISSN
1474-547X
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(03)13913-X