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- Title
Is Candida albicans a trigger in the onset of coeliac disease?
- Authors
Nieuwenhuizen, W F; Pieters, R H H; Knippels, L M J; Jansen, M C J F; Koppelman, S J
- Abstract
Coeliac disease is a T-cell-mediated autoimmune disease of the small intestine that is induced by ingestion of gluten proteins from wheat, barley, or rye. We postulate that Candida albicans is a trigger in the onset of coeliac disease. The virulence factor of C albicans-hyphal wall protein 1 (HWP1)-contains aminoacid sequences that are identical or highly homologous to known coeliac disease-related alpha-gliadin and gamma-gliadin T-cell epitopes. HWP1 is a transglutaminase substrate, and is used by C albicans to adhere to the intestinal epithelium. Furthermore, tissue transglutaminase and endomysium components could become covalently linked to the yeast. Subsequently, C albicans might function as an adjuvant that stimulates antibody formation against HWP1 and gluten, and formation of autoreactive antibodies against tissue transglutaminase and endomysium.
- Publication
Lancet (London, England), 2003, Vol 361, Issue 9375, p2152
- ISSN
1474-547X
- Publication type
Journal Article
- DOI
10.1016/s0140-6736(03)13695-1