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- Title
Oral topiramate for treatment of alcohol dependence: a randomised controlled trial.
- Authors
Johnson, Bankole A; Ait-Daoud, Nassima; Bowden, Charles L; DiClemente, Carlo C; Roache, John D; Lawson, Kevin; Javors, Martin A; Ma, Jennie Z
- Abstract
Topiramate, a sulphamate fructopyranose derivative, might antagonise alcohol's rewarding effects associated with abuse liability by inhibiting mesocorticolimbic dopamine release via the contemporaneous facilitation of gamma-amino-butyric acid activity and inhibition of glutamate function. We aimed to see whether topiramate was more effective than placebo as a treatment for alcohol dependence.
- Publication
Lancet (London, England), 2003, Vol 361, Issue 9370, p1677
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(03)13370-3