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- Title
Effect of gabapentin on nausea induced by chemotherapy in patients with breast cancer.
- Authors
Guttuso, Thomas, Jr; Roscoe, Joseph; Griggs, Jennifer
- Abstract
In an anecdotal report, complete resolution of chemotherapy-induced nausea was seen in a patient with breast cancer, after she was placed on the anticonvulsant gabapentin. On this basis, we did an open-label study in which oral gabapentin 300 mg thrice daily was given for every other chemotherapy treatment in nine patients with breast cancer. Six of the nine reported at least a three-point improvement in peak delayed nausea (on an eight-point nausea scale), and three patients had complete resolution of nausea when taking gabapentin. This preliminary evidence shows that gabapentin might have a role in treatment of chemotherapy-induced nausea.
- Publication
Lancet (London, England), 2003, Vol 361, Issue 9370, p1703
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(03)13365-X