We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Coeliac disease--a meeting point for genetics, immunology, and protein chemistry.
- Authors
Mowat, Allan McI
- Abstract
Coeliac disease is caused by a genetically determined, specific immune response to antigens present in wheat gluten. This immune response may be focused on a limited region of the alpha gliadin component of gluten, and previous studies have suggested that the generation of epitopes for recognition by CD4+ T cells requires deamidation of the protein by tissue transglutaminase. However, it had not previously been shown that candidate epitope peptides could be generated from gluten in vivo, or that these epitopes were selective products of physiological digestion of gluten by tissue transglutaminase.
- Publication
Lancet (London, England), 2003, Vol 361, Issue 9365, p1290
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/s0140-6736(03)12989-3