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- Title
Effect of recombinant activated factor VII on perioperative blood loss in patients undergoing retropubic prostatectomy: a double-blind placebo-controlled randomised trial.
- Authors
Friederich, Philip W; Henny, Christiaan P; Messelink, Embert J; Geerdink, Mark G; Keller, Tymen; Kurth, Karl-Heinz; Büller, Harry R; Levi, Marcel
- Abstract
Recombinant activated factor VII (factor VIIa) has prohaemostatic effects in bleeding patients with coagulation abnormalities. We aimed to test the hypothesis that recombinant factor VIIa could reduce perioperative blood loss in patients with normal coagulation systems. Therefore, we assessed safety and efficacy of this drug in patients undergoing retropubic prostatectomy, which is often associated with major blood loss and need for transfusion.
- Publication
Lancet (London, England), 2003, Vol 361, Issue 9353, p201
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(03)12268-4