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- Title
Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?
- Authors
Cheung, C Y; Poon, L L M; Lau, A S; Luk, W; Lau, Y L; Shortridge, K F; Gordon, S; Guan, Y; Peiris, J S M
- Abstract
In 1997, the first documented instance of human respiratory disease and death associated with a purely avian H5N1 influenza virus resulted in an overall case-fatality rate of 33%. The biological basis for the severity of human H5N1 disease has remained unclear. We tested the hypothesis that virus-induced cytokine dysregulation has a role.
- Publication
Lancet (London, England), 2002, Vol 360, Issue 9348, p1831
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/s0140-6736(02)11772-7