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Title
Hypospadias in sons of women exposed to diethylstilbestrol in utero: a cohort study.
Authors
Klip, Helen; Verloop, Janneke; van Gool, Jan D; Koster, Marlies E T A; Burger, Curt W; van Leeuwen, Flora E; OMEGA Project Group
Abstract
Transgenerational effects of diethylstilbestrol (DES) have been reported in animals, but effects in human beings are unknown. Alerted by two case reports, we aimed to establish the risk of hypospadias in the sons of women who were exposed to DES in utero.