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- Title
Safety and antigenicity of non-adjuvanted and MF59-adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a randomised trial of two potential vaccines against H5N1 influenza.
- Authors
Nicholson, K G; Colegate, A E; Podda, A; Stephenson, I; Wood, J; Ypma, E; Zambon, M C
- Abstract
In 1997, pathogenic avian influenza A/Hong Kong/97 (H5N1) viruses emerged as a pandemic threat to human beings. A non-pathogenic variant, influenza A/Duck/Singapore/97 (H5N3), was identified as a leading vaccine candidate. We did an observer-blind, phase I, randomised trial in healthy volunteers to assess safety, tolerability, and antigenicity of MF59-adjuvanted and non-adjuvanted vaccines.
- Publication
Lancet (London, England), 2001, Vol 357, Issue 9272, p1937
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(00)05066-2