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- Title
Effect of pravastatin on frequency of fracture in the LIPID study: secondary analysis of a randomised controlled trial. Long-term Intervention with Pravastatin in Ischaemic Disease.
- Authors
Reid, I R; Hague, W; Emberson, J; Baker, J; Tonkin, A; Hunt, D; MacMahon, S; Sharpe, N
- Abstract
Statins inhibit the same biochemical pathway as aminobisphosphonates, therefore these cholesterol-lowering agents may have a beneficial effect on osteoporosis. This possibility has been supported by the finding that some statins also stimulate bone formation, and by observational studies suggesting that patients using statins have higher bone densities and lower fracture rates than controls. To assess whether statins have clinically significant effects on bone, we studied the frequency of fractures in a large randomised controlled trial of these agents.
- Publication
Lancet (London, England), 2001, Vol 357, Issue 9255, p509
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/s0140-6736(00)04042-3