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- Title
Increased mitochondrial toxicity with ribavirin in HIV/HCV coinfection.
- Authors
Lafeuillade, A; Hittinger, G; Chadapaud, S
- Abstract
In two of 15 patients coinfected with HIV and hepatitis C virus who received interferon-alpha plus ribavirin in addition to HAART, we observed multiorgan dysfunction and lactic acidaemia. As ribavirin is a nucleoside analogue, an increased risk of mitochondrial toxicity can be induced in HIV-infected patients already treated with nucleoside analogues, leading to clinical deterioration in some cases.
- Publication
Lancet (London, England), 2001, Vol 357, Issue 9252, p280
- ISSN
0140-6736
- Publication type
Commentary
- DOI
10.1016/S0140-6736(00)03618-7