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- Title
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.
- Authors
Leckie, M J; ten Brinke, A; Khan, J; Diamant, Z; O'Connor, B J; Walls, C M; Mathur, A K; Cowley, H C; Chung, K F; Djukanovic, R; Hansel, T T; Holgate, S T; Sterk, P J; Barnes, P J
- Abstract
Interleukin-5 (IL-5) is essential for the formation of eosinophils, which are thought to have a major role in the pathogenesis of asthma and other allergic diseases. We aimed to assess the effects of monoclonal antibody to IL-5 on blood and sputum eosinophils, airway hyper-responsiveness, and the late asthmatic reaction to inhaled allergen in patients with mild asthma.
- Publication
Lancet (London, England), 2000, Vol 356, Issue 9248, p2144
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/s0140-6736(00)03496-6