We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study.
- Authors
McKeith, I; Del Ser, T; Spano, P; Emre, M; Wesnes, K; Anand, R; Cicin-Sain, A; Ferrara, R; Spiegel, R
- Abstract
Dementia with Lewy bodies is a common form of dementia in the elderly, characterised clinically by fluctuating cognitive impairment, attention deficits, visual hallucinations, parkinsonism, and other neuropsychiatric features. Neuroleptic medication can provoke severe sensitivity reactions in patients with dementia of this type. Many deficits in cholinergic neurotransmission are seen in the brain of patients with Lewy-body dementia; therefore, drugs enhancing central cholinergic function represent a rationally-based therapeutic approach to this disorder. Rivastigmine, a cholinesterase inhibitor, was tested in a group of clinically characterised patients with Lewy-body dementia.
- Publication
Lancet (London, England), 2000, Vol 356, Issue 9247, p2031
- ISSN
0140-6736
- Publication type
Journal Article
- DOI
10.1016/S0140-6736(00)03399-7