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- Title
Transmission of BSE by blood transfusion in sheep.
- Authors
Houston, F; Foster, J D; Chong, A; Hunter, N; Bostock, C J
- Abstract
We have shown that it is possible to transmit bovine spongiform encephalopathy (BSE) to a sheep by transfusion with whole blood taken from another sheep during the symptom-free phase of an experimental BSE infection. BSE and variant Creutzfeldt-Jakob disease (vCJD) In human beings are caused by the same infectious agent, and the sheep-BSE experimental model has a similar pathogenesis to that of human vCJD. Although UK blood transfusions are leucodepleted--a possible protective measure against any risk from blood transmission--this report suggests that blood donated by symptom-free vCJD-infected human beings may represent a risk of spread of vCJD infection among the human population of the UK.
- Publication
Lancet (London, England), 2000, Vol 356, Issue 9234, p999
- ISSN
0140-6736
- Publication type
Research
- DOI
10.1016/s0140-6736(00)02719-7