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- Title
Role of energy metabolism in the preconditioned heart--a possible contribution of mitochondria.
- Authors
Takeo, S; Nasa, Y
- Abstract
A brief period of ischemia and reperfusion has been shown to protect the myocardium against subsequent sustained ischemia and reperfusion injury, which is called "preconditioning". A great number of investigators have explored the mechanisms underlying this preconditioning-induced cardioprotection. This article dealt with possible mechanisms of energy metabolism and mitochondrial activity for preconditioning-induced cardioprotection. Particularly, the contribution of energy metabolites produced during a brief period of ischemia and reperfusion injury, as well as mitochondrial function that is modified by changes in mitochondrial ATPase activity, opening of mitochondrial ATP-dependent potassium channels and production of free radicals in mitochondria, to ischemic preconditioning is discussed.
- Publication
Cardiovascular research, 1999, Vol 43, Issue 1, p32
- ISSN
0008-6363
- Publication type
Journal Article
- DOI
10.1016/s0008-6363(99)00079-6