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- Title
Pause induced early afterdepolarizations in the long QT syndrome: a simulation study.
- Authors
Viswanathan, P C; Rudy, Y
- Abstract
The long QT syndrome (LQTS) is characterized by prolonged repolarization and propensity to syncope and sudden death due to polymorphic ventricular tachycardias such as torsade de pointes (TdP). The exact mechanism of TdP is unclear, but pause-induced early afterdepolarizations (EADs) have been implicated in its initiation. In this study we investigate the mechanism of pause-induced EADs following pacing at clinically relevant rates and characterize the sensitivity of different cell types (epicardial, midmyocardial, and endocardial) to EAD development.
- Publication
Cardiovascular research, 1999, Vol 42, Issue 2, p530
- ISSN
0008-6363
- Publication type
Journal Article
- DOI
10.1016/s0008-6363(99)00035-8