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Title
Cytokine-induced venodilatation in humans in vivo: eNOS masquerading as iNOS.
Authors
Bhagat, K; Hingorani, A D; Palacios, M; Charles, I G; Vallance, P
Abstract
Venodilatation is a feature of endotoxaemia and sepsis. We have tested directly the hypothesis that three cytokines (IL-1 beta, TNF alpha and IL-6) generated during endotoxaemia affect venous tone in humans in vivo by increasing NO generation and explored whether the NO comes from the iNOS or eNOS isoform.